2025/06/25
Allergies affect millions of people each year, causing symptoms like sneezing, itching, watery eyes, and congestion.136 Antihistamines are an effective way to manage these symptoms by blocking histamine, the chemical responsible for allergic reactions.136 But not all antihistamines work the same way. Understanding the different types of antihistamines and how to use them can help you choose the right one for your needs.

You can find a wide range of trusted antihistamine products to help you manage allergy symptoms effectively. In this guide, we'll explore three trusted products: Allergex® Non Drowsy, Tellerge, and Nazene® Z.
Antihistamines work by blocking histamine receptors in the body.136 Histamine is released by the immune system in response to allergens such as pollen, dust mites, pet dander, and insect bites.136
The two main types of antihistamines:
Each type has specific benefits depending on the severity of symptoms and whether daytime or nighttime use is preferred.
Antihistamines can also come in different forms including tablets, topical creams or drops, nasal sprays, and syrups.
First-generation antihistamines were the first allergy medications developed. While they are effective, they can cause drowsiness because they cross the blood-brain barrier and affect the central nervous system. These antihistamines provide relief for 4-6 hours.178
However, if you need to stay alert during the day, a second-generation, non-drowsy antihistamine is a better choice.
Second-generation antihistamines are designed to relieve allergy symptoms with minimally sedating effect. They provide long-lasting relief (up to 24 hours) and have fewer side effects.178
Sometimes, allergies cause nasal congestion, making it difficult to breathe. While antihistamines reduce sneezing and itching, they don't directly clear a blocked nose.179 Studies have shown that a nasal spray is your best option.179

Nazene® Z (Oxymetazoline)
Nazene® Z Nasal Spray contains oxymetazoline, a decongestant that quickly reduces nasal swelling and congestion by constricting blood vessels in the nasal passages.12
Pro Tip: If allergies leave you feeling blocked up, Nazene® Z can help clear nasal congestion fast - providing relief in less than 5 minutes.69
Regardless of whether you choose a first-generation or second-generation antihistamine, it's important to use them correctly to get the best results.
Still unsure which antihistamine best suits your needs? Here's a quick comparison:
Antihistamines play a crucial role in managing allergies, but choosing the right one depends on your specific symptoms. Second-generation antihistamines like Allergex® Non Drowsy and Tellerge provide all-day relief without drowsiness,4,5,15 while Nazene® Z clears nasal congestion fast.12
Always consult a healthcare professional before starting any new medication to ensure it's right for you.
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